Five papers.

Live from Europe PMC
01
META-ANALYSISCARDIOLOGY·LIVE API

Efficacy of Oral Chinese Medicine in Regulating the Intestinal Flora of Patients with Chronic Heart Failure: A Meta-Analysis.

Key findingA total of 18 clinical randomized controlled trial studies were included, with a total of 1,455 patients with chronic heart failure, including 731 in the trial group and 724 in the control group. The combination of oral Chinese medicine and conventional treatment had a better effective rate of cardiac function improvement than conventional Western medicine treatment alone.

POPULATION & DESIGNThis meta-analysis was registered with registration number: INPLASY202610010. PubMed, Embase, The Cochrane Library, Web of Science, China Biomedical Literature Database (CBM), China Journal Full Text Database (CNKI), Wanfang Database, and Wipu Database were searched by computer, while domestic and international orthopedic journals were searched manually. Clinical randomized controlled trials related to oral TCM containing danshen and rhubarb in combination with conventional Western medicines for the treatment of chronic heart failure that have been published in the public domain up to July 2024 were collected.

POTENTIAL CLINICAL IMPACTOral preparations containing danshen and rhubarb components of TCM combined with conventional methods for the treatment of chronic heart failure can regulate the intestinal flora of patients. Confirm applicability and limitations in the full paper before changing UK practice.

Europe PMC indexed publicationMeta-Analysis · Europe PMC · 24 October 2026
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02
SYSTEMATIC REVIEWACUTE MEDICINE·LIVE API

Skeletal effects of GLP-1 receptor agonist therapy in adults with overweight or obesity: a systematic review.

Key findingEight RCTs (n = 493) were included. Three trials were at low risk of bias (Eriksson 2019; Hygum 2020; Hansen 2024) and five raised some concerns, principally regarding the randomization process and selective reporting; no agent is supported by more than one trial at low risk of bias.

POPULATION & DESIGNThis PRISMA 2020-compliant systematic review (INPLASY202630076) searched PubMed, Embase, Cochrane CENTRAL, and Google Scholar (January 2015 to July 2026). Eligible randomized controlled trials (RCTs) enrolled adults aged ≥18 years with mean baseline body mass index (BMI) > 25 kg/m², compared a GLP-1 RA with placebo or another antidiabetic therapy for ≥12 weeks, and reported BMD assessed by dual-energy X-ray absorptiometry (DXA). Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB 2) tool and certainty of evidence using GRADE.

POTENTIAL CLINICAL IMPACTThe randomized evidence is too sparse and too clinically heterogeneous to determine the skeletal effects of GLP-1 RA therapy in adults with overweight or obesity. Each agent has been evaluated in at most five small trials, most conducted in adults with type 2 diabetes rather than in adults with obesity alone. Confirm applicability and limitations in the full paper before changing UK practice.

Europe PMC indexed publicationSystematic Review · Europe PMC · 23 October 2026
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03
META-ANALYSISSTROKE & NEUROLOGY·LIVE API

Effectiveness of cardiac resynchronization therapy in cancer therapy-related cardiac dysfunction: a systematic review and meta-analysis.

Key findingThis analysis included four studies (one prospective and three retrospective) comprising 110 patients with CTRCD, the majority (91%, n = 100) being survivors of breast cancer or lymphoma/leukemia. Baseline LVEF ranged from 18.

POPULATION & DESIGNWe performed a literature search of studies showing CRT outcomes in the specific group of CTRCD patients. The outcomes of interest were left ventricular ejection fraction (LVEF) and LV volume improvement. A random effects meta-analysis was done to estimate 95% confidence intervals (CI).

POTENTIAL CLINICAL IMPACTThis meta-analysis suggests that CRT improves LVEF and LV volumes in selected patients with CTRCD, with a magnitude of reverse remodeling that appears similar to that observed in other etiologies of non-ischemic cardiomyopathy. However, the evidence is limited to small observational studies, so conclusions about clinical outcomes remain uncertain. Confirm applicability and limitations in the full paper before changing UK practice.

Europe PMC indexed publicationMeta-Analysis · Europe PMC · 21 October 2026
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04
SYSTEMATIC REVIEWEMERGENCY MEDICINE·LIVE API

POCUS Image Archiving in Emergency Medicine: A Systematic Review of Clinical and Financial Impacts.

Key findingFinancial outcomes were also positively affected, with reported increases in billing compliance, reimbursement, and institutional revenue after workflow integration. Despite these benefits, substantial heterogeneity among studies and limitations regarding study design, confounding factors, and generalizability remain.

POPULATION & DESIGNPoint-of-care ultrasound (POCUS) has become an essential diagnostic tool in emergency medicine, providing rapid bedside information that supports clinical decision-making. However, the full potential of POCUS may extend beyond image acquisition, with effective documentation and integration into electronic health record (EHR) systems potentially contributing to improved clinical and operational outcomes. This systematic review evaluated the clinical, operational, and financial impacts of POCUS image archiving within EHRs in emergency department settings.

POTENTIAL CLINICAL IMPACTFinancial outcomes were also positively affected, with reported increases in billing compliance, reimbursement, and institutional revenue after workflow integration. Despite these benefits, substantial heterogeneity among studies and limitations regarding study design, confounding factors, and generalizability remain. Confirm applicability and limitations in the full paper before changing UK practice.

Europe PMC indexed publicationSystematic Review · Europe PMC · 19 October 2026
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05
RANDOMISED CONTROLLED TRIALCRITICAL CARE·LIVE API

Application of Electrical Impedance Tomography-Guided Pulmonary Rehabilitation Strategy in Patients with Respiratory Failure.

Key finding5%). Respiratory rate decreased, and pulse oxygen saturation increased over time in both groups, without significant group or interaction effects.

POPULATION & DESIGNThis study investigated pulmonary rehabilitation strategies guided by electrical impedance tomography (EIT) in patients with respiratory failure. A total of 92 patients with respiratory failure admitted to the Intensive Care Unit (ICU) of a tertiary Grade A hospital in Chongqing from July 2024 to January 2025 were selected and randomly divided into a control group and an experimental group, with 46 cases in each group, using a random number table. The control group received conventional pulmonary physical therapy nursing strategies.

POTENTIAL CLINICAL IMPACT5%). Respiratory rate decreased, and pulse oxygen saturation increased over time in both groups, without significant group or interaction effects. Confirm applicability and limitations in the full paper before changing UK practice.

Europe PMC indexed publicationRandomised Controlled Trial · Europe PMC · 30 October 2026
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